Effects of carbon disulphide on the liver of rats.

نویسندگان

  • E J Bond
  • W H Butler
  • F De Matteis
  • J M Barnes
چکیده

Bond, E. J., Butler, W. H., de Matteis, F., and Barnes, J. M. (1968). Brit. J. industr. Med., 26, 335-337. Effects of carbon disulphide on the liver of rats. Normal rats surviving a single oral dose of carbon disulphide (CS2) show liver enlargement and depression of drug-metabolizing enzymes but no liver necrosis. If the drug-metabolizing enzymes are stimulated by phenobarbitone before exposure to CS2, the LD50 does not change but liver necrosis is produced.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Antioxidant and Hepatoprotective Effects of Bauhinia racemosa Against Paracetamol and Carbon Tetrachloride Induced Liver Damage in Rats

The methanol extract of Bauhinia racemosa Lam. (Caesalpiniaceae) stem bark was investigated for the antioxidant and hepatoprotective effects in Wistar albino rats. Different groups of animals were administered with paracetamol (500 mg/kg, (p.o.) once in a day for 7 days) and carbon tetrachloride (CCl4) (30 % CCl4, 1 ml/kg b.wt. in liquid paraffin 3 doses (i.p.) at 72 h interval). The methanol e...

متن کامل

Protective Effect of Ricinus communis Leaves Extract on Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats

       Ricinus communis Linn. (Euphorbiaceae) is a soft wooded tree widely prevalent throughout tropics regions of the world which have a warm temperature. In the Indian system of medicine, the leaves, roots and seed oil of this plant have been used for the treatment of inflammation and liver disorders for a lo...

متن کامل

The Effects of Taraxacum officinale L. and Berberis vulgaris L. Root Extracts on Carbon Tetrachloride Induced Liver Toxicity in Rats

  Background: Taraxacum officinale and Berberis vulgaris have long been used as herbal remedies for treatment of a variety of complaints including liver dysfunction and gallbladder disease. However scientifically reliable data are needed to verify their minimum effective doses.   Objective: In present study, the effects of Taraxacum officinale L. and Berberis vulgaris L. root extracts at the di...

متن کامل

Protective Effects of Hydro-alcoholic Extract of Apium Graveolens on Carbon Tetrachloride Induced Hepatotoxicity in Sprague-Dawley male Rats

  Background & Objective: Apium graveolens has antioxidant property because of its flavonoid compounds. In the present study, we investigated the hepatoprotective effects of hydroalcoholic extract of Apium graveolens in Sprague Dawley male rats treated with carbon tetrachloride (CCl4). Materials & Methods: In this study, 48 rats (weighted 180-200 gram) were divided into six groups each having e...

متن کامل

Effect of phenobarbitone and starvation on hepatotoxicity in rats exposed to carbon disulphide vapour.

Magos, L., and Butler, W. H. (1972). Brit. J. industr. Med., 29,95-98. Effect of phenobarbitone and starvation on hepatotoxicity in rats exposed to carbon disulphide vapour. Male albino rats given 80 and 50 mg/kg phenobarbitone sodium by intraperitoneal injection 24 and 18 hours before 4-hour exposure to 2-0 mg/l carbon disulphide (CS2) developed hydropic degeneration in the centrilobular zone ...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • British journal of industrial medicine

دوره 26 4  شماره 

صفحات  -

تاریخ انتشار 1969